Zemuron rocuronium bromide is a nondepolarizing neuromuscular blocking agent given before general anesthesia in preparation for surgery. Highlights of prescribing information these highlights. The plasma halflife of rocuronium in adults with normal renal and hepatic function is about 2. Feb 06, 2009 rocuronium is a nondepolarizing nmba with a steroidal backbone that is commercially prepared in an aqueous solution adjusted to a ph of 4. To overcome this problem, a study with accurate numerators and denominators for the calculation was recently conducted at two hospitals in auckland, new zealand. Prescribing information pfizer medical information us. Each vial contains 10 mg or 20 mg of vecuronium bromide. The following prescribing information is in adobe pdf format. These highlights do not include all the information needed to use.
Establish safeguards and alerts at each step of the medication use process ordering, verifying, dispensing, and administration. Mylan manufactures rocuronium bromide injection zemuron in strengths of 50 mg5 ml 10 mgml100 mg10 ml 10 mgml. Zemuron helps keep the body still during surgery and also relaxes the throat so a breathing tube can be more easily inserted before surgery. Milrinone lactate injection 200 mcgml in 5% dextrose injection description primacor, brand of milrinone lactate injection, is a member of a class of bipyridine inotropicvasodilator agents with phosphodiesterase inhibitor activity, distinct from digitalis glycosides or catecholamines. Rocuronium is a new, nondepolarizing muscle relaxant. Orencia may be used as monotherapy or concomitantly with diseasemodifying, antirheumatic drugs dmards other than tumor. Highlights of prescribing information marked bradycardia.
It is proven to be five to seven times less potent than vecuronium. Rocuronium rocuronium bromide injection is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate onset depending on dose and intermediate duration. If parenteral promethazine must be used, providers and clinicians must follow recommendations per the package insert, ismp, and va medsafe. This results in the reversal of neuromuscular blockade induced by rocuronium and vecuronium. Hazards identification emergency overview rocuronium bromide injection is a solution containing rocuronium bromide, a. The product is for single patient use and contains no antimicrobial agent. The package insert defines low dose rocuronium as a dose of 0. Rocuronium bromide injection sagent pharmaceuticals.
Researchers at organon laboratories new house, uk wanted to solua a. Rocuronium bromide injection zemuron 50 mg5 ml 10 mgml100. Comparison of succinylcholine and rocuronium for first. Side effects of zemuron rocuronium bromide injection. Waxs characterization of our dose as low is inconsistent with. Innovative disruption in the world of neuromuscular. Package insert only rocuronium bromide injection famotidine furosemide solutions should be discarded. Rocuronium is a nondepolarizing nmba with a steroidal backbone that is commercially prepared in an aqueous solution adjusted to a ph of 4. Rocuronium bromide 119302919 1 sodium chloride 7647145 0. It forms a complex with the neuromuscular blocking agents rocuronium and vecuronium, and it reduces the amount of neuromuscular blocking agent available to bind to nicotinic cholinergic receptors in the neuromuscular junction. Description vecuronium bromide for injection is a nondepolarizing neuromuscular blocking agent of intermediate duration, chemically designated as. Rocuronium kabi 10 mgml solution for injection infusion. Rocuronium bromide injection should be stored under refrigeration, 28c 36 46f do not freeze.
Dosing based on actual body weight and depth of block routine coadministration of an anticholinergic agent is not required. Innovative disruption in the world of neuromuscular blockade. Researchers at organon laboratories new house, uk wanted to solubilize rocuronium without the acidic mannitol phosphate buffer solvent used in the current formulation. Primacor, brand of milrinone lactate injection, is a member of a class of bipyridine inotropicvasodilator agents with phosphodiesterase inhibitor activity, distinct from digitalis glycosides or catecholamines. Easytoread drug name and dosage strength to aid in identifying the right product. The metabolite 17desacetyl rocuronium has been rarely observed in the plasma or urine of humans administered single doses of 0. Rocuronium no absolute contraindications succinylcholine chloride package insert rocuronium bromide package insert monday morning in the ed pharmacy buyer pages you succinylcholine is on backorder only have 20 vials in house hospitalhospital uses an average of 10 vials per day. Confirmed cases of allergic reactions to clinical doses of sugammadex have been recently reported 11, 12. Labelingpackage insert label is not available on this site.
Inhalation, ingestion, eye contact, skin absorption. Read all of this leaflet carefully before you are given this medicine because it contains important information for you. As with other neuromuscular blocking agents, the dosage of rocuronium bromide. Doses of rocuronium bromide injection should be individualized and a. Refer to each drugs package insert for indications of use, contraindications, dosage, adverse reactions, etc. Product monograph download pdf, 403kb pfizer canada. If there is a clinical need for immediate reversal following administration of rocuronium a dose of 16mgkg sugammadex is recommended. Discovery, development, and clinical application of. Bridion is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide in adults undergoing surgery. Our dosing and terminology are consistent with the package insert. Rocuronium bromide is a newer, low potency nondepolarising neuromuscular blocking agent. A dose of 2 mgkg is recommended if spontaneous recovery has reached the reappearance of the second twitch t2 in response to tof stimulation following rocuronium or vecuroniuminduced neuromuscular blockade. Current evidence suggests that succinylcholine provides superior intubation conditions to.
Rocuronium no absolute contraindications succinylcholine chloride package insert rocuronium bromide package insert monday morning in the ed pharmacy buyer pages you succinylcholine is on backorder only have 20 vials in house hospitalhospital uses an average of 10 vials per day time to scramble. Atracurium 10 mgml solution for injection or infusion atracurium besilate therapeutic indications atracurium is a highly selective, competitive or non. Vecuronium bromide for injection is supplied as a sterile nonpyrogenic freezedried buffered cake of very fine microscopic crystalline particles for intravenous injection only. Rocuronium bromide is chemically designated as 117. Upon removal from refrigeration to room temperature storage conditions 25c77f use rocuronium bromide injection within 60 days. Sugammadex is the first clinical representative of a class of drugs called steroidal muscle relaxant encapsulators. Rocuronium bromide injection is a sterile, nonpyrogenic, isotonic, clear colorless to yellow or orange solution, free from visible particles and is supplied as follows. To date, the japanese society of anesthesiologists has issued a warning about sugammadexinduced anaphylactic shock five times.
Succinylcholine and rocuronium are the most common paralytic agents used for rapid sequence intubation rsi in the emergency department ed. Department of anesthesiology, university of virginia, health sciences center, box 238, charlottesville, virginia 22908. Information for the user atracurium 10 mgml solution for injection or infusion atracurium besilate the following information is intended for healthcare professionals only. Rocuronium bromide rocuronium bromide dose, indications. When 16mgkg sugammadex is administered 3minutes after a bolus dose of 1. Though their results are comparable with our study with regard to faster onset of action in rocuronium group, in our study onset of action of rocuronium as well as vecuronium was much faster as compared to their study. Dec 23, 2010 this finding is consistent with previous investigations that used doses between 0. Highlights of prescribing information these highlights do not include all the information needed to use rocuronium bromide injection safely and effectively. We have noticed that patients complain of severe burning pain if rocuronium is administered before loss of consciousness after induction of anesthesia or using a priming principle wherein a small subparalyzing dose 10% of an intubating dose of the relaxant can be administered followed by the larger, remaining portion of the. Amerisourcebergen 10102655 cardinal 4559258 hd smith. Sugammadex bridion drug monograph updated august 2016 updated version may be found at. The rocuronium package insert july 2005 states that 0. Pbm guidance promethazinehcl injection,usp phenergan. For information regarding recommended uses and restrictions on usage refer to the product package insert.
Nov 22, 2018 rocuronium bromide injection is a sterile, nonpyrogenic, isotonic, clear colorless to yellow or orange solution, free from visible particles and is supplied as follows. Links to sites outside of pfizer medical information are provided as a resource to the viewer. This results in the reversal of neuromuscular blockade induced by. Readministration of rocuronium or vecuronium after reversal up to 4 mgkg bridion minimum waiting time nmba and dose to be administered 5 minutes 1. Readministration of rocuronium or vecuronium after reversal up to 4 mgkg bridion minimum waiting time nmba and dose to be administered. Bar codes included on the vial and carton for ease of scanning.
The aim of the present study was to evaluate the effectiveness of 2ed95 2 times effective dose 95 dose 0. What rocuronium bromide looks like and contents of the pack rocuronium bromide is a colourless to yelloworange solution for injection. However, the number of reports of sugammadexinduced anaphylaxis is much less than those for nmbas 12. Please see product packaging and package insert for complete expiration date and storage requirements. Rocuronium bromide rocuronium bromide injection, solution hospira, inc. Dec 08, 2015 the variation in the reported incidence of anaphylaxis to rocuronium, approximately 1. The metabolite 17desacetylrocuronium has been rarely observed in the plasma or urine of humans administered single doses of 0. A dose of 16 mgkg is recommended if there is a clinical need to reverse neuromuscular blockade soon 3 minutes. Ephedrine may reduce the onset time of neuromuscular blockade when used for intubation with rocuronium if administered simultaneously with anesthetic induction. This drug should only be administered by experienced clinicians or trained individuals supervised by an experienced clinician familiar with the use, actions, characteristics, and complications of neuromuscular blocking agents. Labelingcontainercarton labels, labelingpackage insert. Primacor milrinone lactate is designated chemically as 1,6. Click here to view the file or click here to download the adobe pdf plugin for your browser. Intramuscular rocuronium in infants and childrenis there.
See full prescribing information for rocuronium bromide injection. The package insert of sugammadex discourages its administration to patients with severe renal dysfunction. Rocuronium bromide is a nondepolarizing neuromuscular blocking agent with a rapid to intermediate. Intramuscular rocuronium in infants and childrenis there a. Infusion solutions of rocuronium bromide injection can be prepared by mixing rocuronium bromide. Rocuronium bromide injection fda prescribing information. Product profile mylan better health for a better world. Treatment with anticholinergic agents, such as atropine, should be administered if clinically significant bradycardia is observed. Amerisourcebergen 105789 cardinal 4972162 hd smith.
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