H 2 so 4 use a dropper, h 2 so 4 is highly corrosive and swirl the flask gently until the salicylic acid dissolves heat the flask gently on the steam bath for at least 10 minutes. In the presence of moisture, aspirin may decompose hydrolysis into salicylic acid and acetic acid. Over the course of the first semester and the beginning of the second, our general chemistry students synthesize two organic substances aspirin and methyl. The reaction that is used for the synthesis is shown below. This is not surprising when one considers the medicinal applications for aspirin. Allow the flask to stand at room temperature until. The polar oxygen accepts the electrons from now positively charged hydrogen. In this experiment, you will measure the melting point of your synthesized asa product, salicylic acid, a crushed aspirin tablet, and pure asa from a manufacturer. Synthesis of aspirin aspirin is the single most manufactured drug in the world. Heating should be continued until the solution is clear. Aspirin, also known as acetylsalicylic acid asa, is a medication used to reduce pain, fever, or inflammation. One of the most widely used nonprescription drugs is aspirin. The antiplatelet activity of aspirin has resulted in a new use for an old drug. This compound had the medicinal properties of salicylic acid, an extract of willow bark.
This paper describes the first of our organic synthesis experiments, the synthesis, purification, and qualitative spectroscopic characterization of aspirin. The purity of the product will be confirmed by measuring its melting point range. The temperature of an alcohol thermometer was equilibrated in a beaker of room temperature tap water. Pdf preparing a pure aspirin acetylsalicylic acid researchgate. Synthesis of aspirin adapted from bettelheim objective. This experiment will demonstrate the preparation of aspirin. Antiinflammatory inhibition of the synthesis of prostaglandins. Tinjauan pustaka esterifikasi adalah reaksi pengubahan dari suatu asam. Synthesis of aspirin introduction aspirin is one of the milder and least expensive pain relievers available. Experiment 8 synthesis of aspirin aspirin is an effective analgesic pain reliever, antipyretic fever reducer and antiinflammatory agent and is one of the most widely used nonprescription drugs.
Synthesis in this experiment, aspirin will be produced by reacting salicylic acid with acetic anhydride, a derivative of acetic acid that has similar chemicals properties to acetic acid, but reacts more rapidly and efficiently. We will prepare aspirin by reacting salicylic acid 1 with an excess of acetic. A greener approach to aspirin synthesis using microwave irradiation. Compare the melting points of your aspirin and pure aspirin. To verify the identity of the aspirin, completely dissolve. Preparation of acetylsalicylic acid aspirin background one of the most widely used nonprescription drugs is aspirin. Pdf the synthesis and analysis of aspirin semantic scholar. The purpose of this experiment is to synthesize a common organic product called acetylsalicylic acid aspirin, and to become familiar with the optimum conditions needed for successful yields. Aspirin synthesis tap water was heated on a steam bath in a 250 ml beaker. In fact, many cultures have used plants containing significant amounts of these compounds in medications to relieve. Though aspirin has numerous benefits, there are several adverse affects as well. Tujuan percobaan memahami reaksi esterifikasi fenol memahami reaksi pembuatan aspirin mampu melakukan uji kadar aspirin hasil reaksi 2. Aspirin is one of the milder and least expensive pain relievers available. Aspirins chemical name is acetylsalicylic acid, and it is synthesized from the reaction of acetic anhydride with salicylic acid in the presence of phosphoric acid as a catalyst.
After synthesis and analysis, it will be determined if the crude and recrystallized samples were composed solely of either salicylic acid, acetylsalicylic acid, or a combination of both 3. Store the aspirin in the desicooler and determine the percent yield of the synthesis by taking the actual yield and dividing it by the theoretical yield, determined from the original amount of salicylic acid used. Theory aspirin, acetylsalicylic acid, was first synthesized in 1893 by felix hofmann, a chemist for the german firm of bayer. Jeana greaves chem3301112 june 19, 20 synthesis of aspirin from methyl salicylate introduction the synthesis of aspirin acetyl salicyclic acid began with methyl salicylate and sodium hydroxide as the reagent. Synthesis of aspirin background aspirin, which ranks as the most widely used drug in the united states, is one of a series of salicylic acid esters that has been known since antiquity to have therapeutic effects. Aspirin may help to decrease the progression of athero. Aspirin given shortly after a heart attack decreases the risk of death. Aspirins chemical name is acetylsalicyl ic acid, and it is synthesized from the reaction of acetic anhydride with salicylic acid in the presence of phosphoric acid as. Preparation, purification and analysis of aspirin acetylsalicylic acid. It is the twostep synthesis of aspirin starting from oil of wintergreen. The synthesis of aspirin chemistry science fair project experiments, chemistry models, exhibition ideas, expo topics for kids and also organics chemistry science ideas for cbse, icse, middleschool, elementary school for 5th, 6th, 7th, 8th, 9th and high school students. Synthesis of aspirin report data collected and subsequent calculations to all equipment should be returned to the correct location after use. Specific inflammatory conditions which aspirin is used to treat include kawasaki disease, pericarditis, and rheumatic fever.
As a current student on this bumpy collegiate pathway, i stumbled upon course hero, where i can find study resources for nearly all my courses, get online help from tutors 247, and even share my old projects, papers, and lecture notes with other students. The mechanism for this synthesis provides examples of three major classes of chemical reactions. Synthesis of aspirin ppt green chemistry filtration. You have been asked to evaluate a simple organic synthesis for aspirin and to determine if the synthesis merits further funding by santa monica pharmaceuticals. The synthesis of aspirin from oil of wintergreen is an example of one of. Synthesis of aspirin ppt free download as powerpoint presentation.
To determine the purity of the aspirin or acetaminophen. The synthesis of aspirin has been a popular experiment in organic chemistry teaching laboratories and even in some introductory chemistry laboratories 1. Synthesizing aspirin and oil of wintergreen purpose in this experiment, you will synthesize acetylsalicylic acid, commonly known as aspirin, and methyl salicylate, oil of wintergreen, from salicylic acid. Your team of scientists has been hired by the drug research division of santa monica. Aspirin is an analgesic pain reliever, an antipyretic fever reducer, and antiinflammatory medicine.
This figure mainly reflects purchase of 16,000 tons of aspirin tablets or 80 million tablets a year. Synthesis of aspirin lab report and analysis odinity. Please attribute this work as being created by the north c. Compound molecular weight hazards density melting point salicylic acid 8. Synthesis of salicylic acid from oil of wintergreen. Prostaglandins were found to be responsible for pain and blood clotting.
Waste salicylic acid should be disposed of in the solid waste container. In the united states, more than 15,000 pounds are sold each year. One of the most consumed drugs production in the us is 10 million kgyear aspirin. Synthesis and analysis of acetyl salicylic acid amy chan chem 290 section 1 november 25, 2002. Aspirin acetylsalicylic acid is a painrelieving compound familiar to virtually all students. The synthesis of aspirin chemistry science fair project. The synthesis and characterization of aspirin part 1 purpose. Synthesis of aspirin and oil of wintergreen the purpose of this experiment was to employ techniques to synthesize aspirin and oil of wintergreen and to purify crude aspirin via recrystallization. Calculate the mass of crude aspirin that you collected.
In june 1971 nature published a seminal paper by john vane and priscilla piper, inhibition of prostaglandin synthesis as a mechanism of action for aspirinlike drugs. Aspirin is superior to salicylic acid for oral dosage in that the latter is very bitter, and causes stomach. This reaction is the reverse of the synthesis reaction. Organic synthesis of aspirin chemistry formal lab essay sample. Aspirin alters the oxygenase activity of prostaglandin synthetase by moving the acetyl group to a terminal amine group4. To synthesize acetylsalicylic acid aspirin, purify it, and determine the percent yield.
First discovered in 1897 by felix hoffman, it has since been used in over 50 overthecounter medicines. Synthesis of aspirin experiment chemistry libretexts. Calculate the percent yield of aspirin amount collected theoretical yield x 100% what is the melt point of your dried aspirin. Chan 1 introduction acetyl salicylic acid, commonly known as aspirin, is one of the most common synthetic medicines. Synthesis of aspirin lab report 1101 words 5 pages. An experiment is described that is suitable for the early portion of the laboratory in a general chemistry course and integrates organic examples. Performs the synthesis of acetylsalicylic acid aspirin purification by recrystallization and using melting point to confirm identity. Aspirin is one of the most widely used nonprescription drugs in the world, with over 50 million pounds consumed annually. Organic synthesis of aspirin chemistry formal lab essay. Pdf this aim of this experiment focuses on the synthesis of pure aspirin acetylsalicylic acid from ethanoic anhydride and salicylic acid while. You will be able to see how two very different organic compounds can be made from the same common starting material.
The synthesis and characterization of aspirin part 1. Aspirin synthesis your team of scientists has been hired by the drug research division of santa monica pharmaceuticals, a new startup company formed by some smc alumni. Since acetic acid is very soluble in water, it is easily separated from the aspirin product. Aspirin is a drug which is widely used today to deal with the symptoms of many minor illnesses ranging from general relief from aches and pain. This aim of this experiment focuses on the synthesis of pure aspirin acetylsalicylic acid from ethanoic anhydride and salicylic acid while using concentrated sulfuric acid as a catalyst for the. Aspirin acetylsalicylic acid is the most common medicinal drug in use today. Synthesis of aspirin synthesis purification characterization. The use of aspirin had its origin in the 18th century, when it was found that an extract from the.
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